Evidence of the Health Benefits of a Low Carb Eating Plan
Videos
The Ketogenic Diet for MS, Autoimmune Disorders,
and Quality of Life
Here you’ll find a listing of articles, videos & research supporting a ketogenic, low-carb diet as therapeutic for autoimmune disease, MS and more.
Dr. Daniel Kantor talks with Dr. Marcus Bahra from Charite Medical University, Berlin about the Ketogenic Diet and the impact it has on Multiple Sclerosis and quality of Life.
So Why Do I Need to be in Ketosis?
Keto Diet Explained with Jong Rho, MD
Understanding the health benefits of a low carb eating plan for cancer, epilepsy, neurological disorders and chronic disease in general.
Studies
- The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis
Multiple Sclerosis International 2015; Volume 2015 Article ID 681289, 9 pages.
“… ketones, and the ketogenic diet have however shown positive results in several models of neurodegeneration …”
“Despite its high fat component, the ketogenic diet is safe and even beneficial for cardiometabolic risk factors. It has been in continuous use for almost a century for the treatment of epilepsy and has shown good tolerability, even in children.”
“Current treatment options in MS affect immune function and relapse rate with little effect on disease progression. They are sometimes accompanied with significant side effects including lymphopenia, multifocal leukoencephalopathy, and malignancy. Consequently, it may be more favourable for some patients to pursue a relatively risk-free dietary approach that has the potential to reduce disease progression without affecting immune response.” - A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.
Cell Reports. 2016; 7;15(10): 2136-2146.
“We also report preliminary data suggesting that an FMD (fasting mimicking diet) or a chronic ketogenic diet are safe, feasible, and potentially effective in the treatment of relapsing-remitting multiple sclerosis (RRMS) patients.” - Reduced Mass and Diversity of the Colonic Microbiome in Patients with Multiple Sclerosis and Their Improvement with Ketogenic Diet.
Frontiers in Microbiology. 2017; 28;8:1141.
“Colonic biofermentative function is markedly impaired in MS patients.The ketogenic diet normalized concentrations of the colonic microbiome after 6 months.” - Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis.
PLOS One. 2012; 7(5), e35476
“the KD (keto diet) significantly attenuated brain inflammation and reversed both memory dysfunction and motor impairment in EAE mice. There is mounting evidence that metabolic substrates (and certain hormones) can reduce inflammatory responses, and as a consequence provide both structural and functional neuroprotective effects. Since the KD is currently available in many clinical centers throughout the world, patients with MS may readily benefit from this non-pharmacological treatment option. In light of the present study and supportive evidence from the literature noted above, prospective, controlled clinical trials assessing the therapeutic effects of the KD now appear warranted.” - The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial.
Lancet Neurology. 2008; 7: 500–506
“… 28 children (38%) in the diet group had greater than 50% seizure reduction … and five children (7%) in the diet group had greater than 90% seizure reduction …”
“The results from this trial of the ketogenic diet support its use in children with treatment-intractable epilepsy.” - A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease.
Nutrition & Metabolism. 2005; 2: 28.I.
“Here we demonstrate that a diet rich in saturated fats and low in carbohydrates can actually reduce levels of Aβ (amyloid-β). Therefore, dietary strategies aimed at reducing Aβ levels should take into account interactions of dietary components and the metabolic outcomes, in particular, levels of carbohydrates, total calories, and presence of ketone bodies should be considered.” - A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis.
BMC Neuroscience. 2006; 7: 29.
“This is the first study showing that diet, specifically a KD, alters the progression of the clinical and biological manifestations of the G93A SOD1 transgenic mouse model of ALS. These effects may be due to the ability of ketone bodies to promote ATP synthesis and bypass inhibition of complex I in the mitochondrial respiratory chain.” - Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet.
PLOS One. 2009; 23; 4(12):e8349.
“These data suggest that applying a keto diet or exploiting cellular mechanisms associated with ketone-based metabolism offers new therapeutic opportunities for controlling pain and peripheral inflammation, and that such a metabolic strategy may offer significant benefits for children and adults.”
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