Changes in the Microbiome of MS Patients

An image of an MS patient

 

Two scientific reviews published this month discuss very important insights into the real cause of MS. One was published in the journal Biomolecules, and the second in the Lancet. Both reviews are focused on research that is leading us in the right direction to find a cure for multiple sclerosis. These researchers are on the right track!

 

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Let’s first define four important terms:

  1. The microbiota refers to all of the microbes that live in our body. Too many disease-causing microbes and not enough health-promoting microbes will cause inflammation and autoimmune reactions. Over the past 10 years, researchers have gained a better understanding of the role that the microbiota plays in regulating the Gut-Brain Axis to maintain our health. The microbiota also plays a vital role in how the innate and adaptive immune responses function. 
  1. The microbiome refers to all of the microbes that live in our body plus their genes (their genetic material). 
  1. Dysbiosis occurs when the microbes that live in the body are out of balance: too many disease-causing microbes and not enough health-promoting microbes are present in the body. It is well known in science that dysbiosis in the intestines can lead to inflammation in the central nervous system (CNS). 
  1. The Gut-Brain Axis is a two-way communication network between the gut microbes and our body, which includes the CNS. It is involved in regulating nerves, hormones, the immune system and brain health. When it is not working properly, people suffer from inflammation, mental health disorders and neurological diseases like MS.

The types of microbes that live in the GI tract vary greatly depending on their location in the GI tract but also on the age of the person.

The microbes that live in the human gut have a profound influence on human health.

Understanding how the microbes that live in our body impact health and disease is the most heavily researched topic in science today. Studies have identified specific microbes that are associated with a variety of human diseases.

The Microbiota and MS

The number of people diagnosed with MS has been increasing globally for decades. There are almost 3 million people who suffer from multiple sclerosis. The cause of MS is still unknown and there is no cure.

It is thought that obesity, low vitamin D, smoking, the Epstein-Barr virus and stress could potentially be environmental risk factors for MS. But this has not been proven.

A large and ever-growing body of research suggests that disruptions in the microbiome of MS patients may be the environmental risk factor for developing MS and may influence the immune system and the course of the disease.

Studies have shown that the microbiota or types of microbes that live in MS patients are very different from the microbes that live in healthy people.

Evidence That Altered Microbiota of MS Patients Could be the Risk Factor For Developing MS

In one study, fecal microbiota samples were transferred from the GI tract of MS patients to mice. The mice then spontaneously developed signs of MS.

In a second study, researchers transferred fecal microbiota from MS patients or healthy subjects into germ-free mice. The mice were then given the myelin antigen to induce the experimental model for MS in the mice – experimental autoimmune encephalitis (EAE). The researchers found that CNS inflammation was more serious in the mice that received MS patient derived fecal samples compared with those transferred with fecal samples of healthy subjects.

These 2 studies showed that the microbiota of MS patients had disease-enhancing effects. 

Evidence that Fecal Microbiota Transplantation (FMT) Can Miraculously Improve MS Symptoms

FMT is a therapy that transfers a solution of fecal matter from a healthy donor into the GI tract of a recipient. This is done to change the recipient’s gut microbiota and improve their health. It has been used to successfully treat recurring Clostridium difficile infections but it may also be helpful for inflammatory bowel disease, obesity, metabolic syndrome and functional gastrointestinal disorders.

There are case reports of miraculous benefits of FMT in MS patients.

In the first study, after FMT treatment for constipation, three wheelchair-bound MS patients had such dramatic improvements in their neurological symptoms that they were able to walk again without assistance.

A second study reported that after FMT, an MS patient had an improved gait, no relapses while being monitored for a year, and had higher levels of brain derived neurotrophic factor (BDNF) which is known to be low in those with MS.

The fact that 3 wheelchair-bound MS patients had such dramatic symptom improvements where they came out of their wheel chairs and were able to walk again without help after FMT, is so significant and it is surprising that there isn’t more interest in this research.

Real Solutions for Today!

If you’re frustrated with the fact that our standard of care STILL doesn’t offer a real solution for treating MS then click on the link below to watch my free masterclass training and discover REAL solutions that have allow myself and many others to live free of MS symptoms.

CLICK Here to watch Pam’s masterclass training

References:

A multiple sclerosis patient-oriented multiomics analysis tells us where to go next: Commentary for: “Alterations of host-gut microbiome interactions in multiple sclerosis”

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

Author Pam Bartha

Clinically diagnosed with multiple sclerosis at the age of 28, Pam chose an alternative approach to recovery. Now decades later and still symptom free, she coaches others on how to treat the root cause of chronic disease, using a holistic approach. She can teach you how, too.

Pam is the author of Become a Wellness Champion and founder of Live Disease Free. She is a wellness expert, coach and speaker.

The Live Disease Free Academy has helped hundreds of Wellness Champions in over 15 countries take charge of their health and experience profound improvements in their life.

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